Marathon Running and Biomarkers of Acute Kidney Injury
This study is the first to examine the effect of marathon running on TIMP-2 and IGFBP, two urinary biomarkers of cell cycle arrest that strongly predict development of AKI in clinical populations. TIMP-2 and IGFBP7 increased following marathon running and this rise was moderately correlated with the rise in serum creatinine. Adjusting the TIMP-2 and […]
Frailty following Ischaemic Stroke
Frailty, Assessed by the Rockwood Clinical Frailty Scale and 1-Year Outcomes Following Ischaemic Stroke in a Non-Specialist UK Stroke Centre Frailty, assessed by the clinical frailty scale (CFS), is independently associated with 28-day and 1-year mortality after ischaemic stroke. In contrast to previous work, improvement in stroke severity following thrombolysis was not attenuated with frailty. […]
Urinary Assays for Predicting Severe AKI
New Publication Sussex Critical is pleased to announce a new publication in the prestigious journal of the American Society of Nephrology, Kidney360. Acute Kidney Injury is a potentially life-threatening disease that remains notoriously difficult to diagnose and prevent. This paper evaluates a potentially useful urinary assay in predicting Severe AKI. The urinary assay of C-C […]
OPERA Score – Risk Stratification in Older Adults Admitted to Hospital
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248477 Demographic changes alongside medical advances have resulted in older adults accounting for an increasing proportion of emergency hospital admissions. Current measures of illness severity, limited to physiological parameters, have shortcomings in this cohort, partly due to patient complexity. This study aimed to derive and validate a risk score for acutely unwell older adults which […]
Frailty Assessment
Meeting the needs of an ageing society is one of the Governments’ ‘Grand Challenges.’ In coastal West Sussex, 25% of the population are over 65, a statistic England overall is projected to reflect by 2035. Emergency departments (EDs) have experienced increased attendances of older people and delivery of high quality, holistic care requires accurate screening […]
NEWS, Lactate and Sepsis
This project included a number of trainee doctors led by Dr Duncan Hargreaves and BSMS medical students Joshua de Carvalho and Laura Smith. A prospectively gathered cohort of 1233 adults brought in by ambulance with suspicion of sepsis was analysed. Associations with 30-day mortality and ICU admission rate were compared between groups with an elevated […]
Liver disease
Acute hepatic dysfunction in the critically ill population with pre-existing liver cirrhosis is associated with a high mortality. Several prediction models have been developed to risk stratify patients with liver disease. In a dual-centre study we validated a recently described model against other prediction models and described long-term outcomes of the cohort. This work was […]
Sodium Bicarbonate in AKI
As part of a National team we will be investigating the use of sodium bicarbonate in a multi-centre randomised controlled trial beginning in 2021 funded through the NIHR HTA. Around 184,000 critically ill adults are admitted to critical care units each year in the UK. Around half have a sudden worsening in kidney function that […]
ICE-AKI Study
Background: Acute kidney injury (AKI) is assoicated with high mortality and measures to improve risk stratification and early identification have been urgently called for. This study investigated whether an electronic clinical prediction rule (CPR) combined with an AKI e-alert could reduce hospital-acquired AKI (HA-AKI) and improve associated outcomes. Methods and findings: A controlled before-and-after study included 30,295 […]